The DNA Repair formula contains Pterocarpus and Gotu-Kola to Repair DNA along with Cocoa Extract to Protect DNA by reducing chronic inflammation:
Pterocarpus Extract contains pterostilbene a compound that activates DNA repair through the AMP-activated protein kinase (AMPK) pathway and the SIRT1 pathway. It is closely related to resveratrol, but 4 times more potent due to superior bioavailability.
- AMPK acts as a metabolic switch that promotes cellular repair and survival by halting energy-intensive growth processes. During periods of energy stress, such as nutrient deprivation or exercise, AMPK is activated and shifts cellular resources from building new macromolecules to conserving energy and repairing existing damage. This switch is a fundamental, evolutionarily conserved mechanism for maintaining energy homeostasis and cell viability under stress. This pause allows the cell time to perform DNA repair before dividing.
- SIRT1 plays a crucial role in regulating metabolism. It improves insulin sensitivity by repressing the protein PTP1B, a negative regulator of insulin signaling. It promotes fat breakdown by repressing the transcription factor PPAR-gamma. It is involved in homologous recombination, a process that repairs DNA double-strand breaks. The loss of SIRT1 is linked to premature aging phenotypes, possibly due to impaired DNA repair.
Cocoa Extract: According to the "COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial" Cocoa Extract supplementation has been shown to reduce CVD death by 27% among older adults (over 60) partly by lowering the high-sensitivity C-reactive protein (hsCRP) marker of inflammation, a key factor in age-related chronic inflammation known as "inflammaging".
The beneficial effects of Cocoa Extract are attributed to the flavanols, potent compounds found in cocoa, which act as antioxidants and improve vascular function, blood pressure, and blood sugar control. The anti-inflammatory effect of the cocoa flavanols is thought to contribute to its observed heart-protective benefits. https://pubmed.ncbi.nlm.nih.gov/3529496
Gotu Kola Extract has been shown to increase the length of telomeres in animal models.
The Telomere Theory of Aging, also known as the Cellular Clock Theory, posits that telomeres, protective caps at the ends of chromosomes, shorten with each cellular division, and this "shortening" limits cell division, leading to cellular senescence and contributing to aging and age-related diseases. Studies indicate that the triterpenes found in Gotu Kola, such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, possess antioxidant and antiapoptotic properties that may contribute to telomere protection.
